Mechanics of the Growth Process (Cont'd)
The Growth Process is activated by elevated levels of Complex X in the bloodstream. Numerous studies have confirmed that elevated blood levels of Complex X induces the secretion of a cascade of substances – human growth hormone ("HGH") and other growth hormones, steroids, brain-derived neurotrophic factor ("BDNF"), AMP-activated protein kinase, stem cells and other progenitor cells and every other substance that is associated with growth or rejuvenation. The blood levels of all of these substances increases in proportion to the increases in blood levels of Complex X. And lactate, the primary component of Complex X, is the preferred fuel source of every organ in the body during the Growth Process. Thus, Complex X is the gatekeeper, regulator and fuel source for the Growth Process.
One of the critical components of the Growth Process is HGH. Among other things, HGH is associated with growth and health of all organs other than the brain, and it is necessary in order to achieve growth in muscle mass. HGH is produced by the pituitary gland. In healthy people (people who are not suffering from advanced FDS), the pituitary gland produces plenty of HGH. However, because elevated levels of HGH in the bloodstream are inconsistent with homeostasis, HGH is metabolized very quickly. Thus, rather than secrete a constant flow of HGH, the pituitary gland stores the HGH until it receives a signal to release it. HGH is released into the bloodstream during intense exercise. This process occurs so dependably that it is known as “Exercise-Induced Human Growth Hormone Response” or EIGR. We know that EIGR is triggered by elevated levels of Complex X rather than the exercise itself because a study of people who cannot produce lactate (the major component of Complex X) showed that those people did not demonstrate EIGR.
The same process occurs with respect to the other substances that have been identified as being components of the Growth Process. Study after study has shown that elevated levels of Complex X in the blood result in almost instantaneous increases in the levels of BDNF in the blood. BDNF can be likened to HGH for the brain. Among other things, BDNF triggers the growth of new neurons and helps repair and protect brain cells from degeneration. Like HGH, BDNF is always available, but it is not released into the bloodstream until the elevated levels of Complex X signal that the Growth Process is underway. Significantly, studies have shown that the increased levels of BDNF are proportional to the increases in the levels of Complex X. Complex X is not just the gatekeeper, it is also the regulator of the Growth Process.
The Growth Process involves the complex interaction of dozens of different substances. Many of the substances involved in the process are ineffective in the absence of others, and some are harmful if not metabolized quickly. The presence in the bloodstream of many of the components of the Growth Process is incompatible with homeostasis. Thus, as noted elsewhere, it must be triggered by a particular stimulus and occur quickly. But why is Complex X, which is synthesized as a result of intense exercise, that trigger?
A critical aspect of the Growth Process is that it is metabolically demanding – growing/rejuvenation takes a lot of energy, and that energy must come from the metabolism of glucose. The brain needs a constant supply of blood glucose. Fueling the Growth Process from blood glucose would put the brain at risk that blood glucose would fall below the levels necessary to maintain proper brain function. Muscle glycogen is the primary means of storing glucose in healthy humans. When a human exercises with intensity, muscle glycogen is used as the primary fuel in a process known as anaerobic metabolism. But only a small percentage of the available glucose is converted into energy and used by the working muscles. Most of the glycogen is turned into Complex X and enters the bloodstream. If the exercise is intense enough, the Complex X is circulated throughout the body. Studies have shown that the lactate that comprises most of Complex X is the preferred fuel of all organs during intense exercise/the Growth Process. The Growth Process occurs during and immediately following intense exercise because that’s when fuel in the form of the lactate that is the major component of Complex X is released from storage in the muscles and made available to the rest of the body to fuel the Growth Process.